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Acetone → HCID 58415471, 화합물

HRID 46173
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HRID 46173 반응식
[CH2:1]([C:8]1([C:20]2[CH:25]=[CH:24][C:23](Br)=[CH:22][CH:21]=2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]2=[N:17][CH:18]=[CH:19][N:9]12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Li]CCCC.[CH3:32][C:33]([CH3:35])=[O:34]>C1COCC1>[CH2:1]([C:8]1([C:20]2[CH:25]=[CH:24][C:23]([C:33]([OH:34])([CH3:35])[CH3:32])=[CH:22][CH:21]=2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]2=[N:17][CH:18]=[CH:19][N:9]12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 180Acetone2회HCID 462065995-benzyl-5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindoleHCID 178418339Butyllithium

생성물 1

HCID 58415471HCID 58415471, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
-78 °C

실험 절차

A suspension of 5-benzyl-5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindole (100 mg) in THF (3 mL) was cooled to −78° C. and n-BuLi solution (0.234 mL, 1.6 M in hexane) was added slowly. After stirring for 10 minutes acetone (29 mg) was added to the resulting red solution. After 30 min of the addition of acetone, reaction was quenched with aqueous saturated NH4Cl. The reaction mixture was partitioned between saturated aqueous NH4Cl and EtOAc.

후처리

  1. additionwas added to the resulting red solution
  2. customwas quenched with aqueous saturated NH4Cl
  3. customThe reaction mixture was partitioned between saturated aqueous NH4Cl and EtOAc

출처 및 근거

ORD 기록
ord-b124a95cab3e49e289e30ce845b760a1
출처 데이터셋
uspto-grants-2013_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08541595B2

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