Acetylalanylalanylleucine benzyl ester → HCID 54064604, 화합물

HRID 461787

반응식

HRID 461787 반응식
C([O:8][C:9](=[O:29])[C@H:10]([CH2:25][CH:26]([CH3:28])[CH3:27])[NH:11][C:12](=[O:24])[C@H:13]([CH3:23])[NH:14][C:15](=[O:22])[C@H:16]([CH3:21])[NH:17][C:18](=[O:20])[CH3:19])C1C=CC=CC=1>C(O)C.[Pd]>[C:18]([NH:17][C@H:16]([C:15]([NH:14][C@H:13]([C:12]([NH:11][C@H:10]([C:9]([OH:29])=[O:8])[CH2:25][CH:26]([CH3:27])[CH3:28])=[O:24])[CH3:23])=[O:22])[CH3:21])(=[O:20])[CH3:19]

참가 물질

4

반응물 1

HCID 54388809Acetylalanylalanylleucine benzyl ester

생성물 1

HCID 54064604HCID 54064604, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Acetylalanylalanylleucine benzyl ester (2 mmole) is dissolved in denaturated ethyl alcohol (0.5 gal. benzene added to 100 gal. of absolute ethanol) (15 ml) and hydrogenated over 10% palladium/charcoal (0.1 gm) at 40 psi for 1/2 hour. The solution was filtered through Celite and evaporated in vacuo. The residue is triturated with diethyl ether to give crystalline acetylalanylalanylleucine, m.p. 185°-186°.

후처리

  1. filtrationThe solution was filtered through Celite
  2. customevaporated in vacuo
  3. customThe residue is triturated with diethyl ether

출처 및 근거

ORD 기록
ord-4a39032193a84006bd99d2a29fe53003
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04064236

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