Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
delta-Gluconolactone → 1-Naphthalenemethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | delta-Gluconolactone | HCID 7027 | — |
| 반응물 | Boron trifluoride etherate | HCID 8000 | — |
| 반응물 | Triethylsilane | HCID 12052 | — |
| 반응물 | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| 생성물 | 1-Naphthalenemethanol | HCID 20908 | — |
반응 단계
As in Reaction Scheme 2, lithium-halogen exchange of compound (76), followed by addition of the resulting nascent lithiated aromatic to perbenzylated gluconolactone (2), produces a mixture of the corresponding lactols, which is reduced using triethylsilane and boron trifluoride etherate. Subsequent desilylation using tetrabutylammonium fluoride (TBAF) affords 1-naphthalenemethanol (77) in a reasonable yield for the three steps.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541380B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-bfedbb9e980745f9992a4ed0ae39d433 |
| 출처 메모 | uspto-grants-2013_09 |