Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 3-Tert-butyl-4-hydroxy-5-iodobenzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | 3-(tert-Butyl)-4-hydroxybenzaldehyde | HCID 3017618 | — |
| 반응물 | Potassium | HCID 5462222 | — |
| 촉매 | Sodium Pyrosulfite | HCID 656671 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Tert-butyl-4-hydroxy-5-iodobenzaldehyde | HCID 18677384 | 131.4% |
반응 단계
A slurry of 3-tert-butyl-4-hydroxybenzaldehyde (16 gm) sodium hydroxide (3.5 gm), potassium iodide (10.3 gm), potassium in distilled water (91 ml) was added dropwise during 20 mins to a stirred solution of ethanol (69 ml), water (15 ml) and and concentrated sulphuric acid (7.5 ml) at 50°-55° C. After addition, the mixture was refluxed for 1 hour. Sodium metabisulphite (1 gm) was added to the mixture and on cooling a precipitate formed. The precipitate was collected and recrystallised from petroleum ether to give 3-tert-butyl-4-hydroxy-5-iodobenzaldehyde (24.8 gm) m.p. 124°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04064266 |
| 출처 데이터셋 | uspto-grants-1977_12 |
| ORD ID | ord-d830b619a9db46d7bc115f370cd80d0c |
| 출처 메모 | uspto-grants-1977_12 |