Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylbenzoyl Chloride → 2'-[2-(1-Methyl-2-piperidyl)ethyl]-p-toluanilide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylbenzoyl Chloride | HCID 13405 | — |
| 반응물 | 2-(2-Aminophenethyl)-1-methylpiperidine | HCID 11085282 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 2'-[2-(1-Methyl-2-piperidyl)ethyl]-p-toluanilide | HCID 20560077 | — |
반응 단계
Reaction of 2-(o-aminophenethyl)-1-methylpiperidine (80 g., 0.036 mole) with p-toluoyl chloride (6.2 g., 0.04 mole) in 50 ml. of pyridine according to the method of Example 25 provides 2'-[2-(1-methyl-2-piperidyl)ethyl]p-toluanilide. Crystallization from isopropyl ether and then from isopropyl alcohol provides 3.9 g., (32%) of analytically pure material, m.p. 90.5°-92° C. (corr.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04064254 |
| 출처 데이터셋 | uspto-grants-1977_12 |
| ORD ID | ord-3f77562955d5417f9a6c43a0fda27edb |
| 출처 메모 | uspto-grants-1977_12 |