Tetrahydrofuran → 2-(Bicyclo[2.2.1]hept-7-yl)ethylamine

HRID 461988노트

반응식

HRID 461988 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].O1CCCC1.[CH:12]12[CH:18]([CH2:19][C:20]([NH2:22])=O)[CH:15]([CH2:16][CH2:17]1)[CH2:14][CH2:13]2>O>[CH:15]12[CH:18]([CH2:19][CH2:20][NH2:22])[CH:12]([CH2:17][CH2:16]1)[CH2:13][CH2:14]2

참가 물질

5

반응물 3

HCID 8028Tetrahydrofuran2회HCID 21226445Aluminium lithium hydride2회HCID 57053985Bicyclo[2.2.1]hept-7-yl acetamide

생성물 1

HCID 213919412-(Bicyclo[2.2.1]hept-7-yl)ethylamine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

0.0425 Mole of lithium aluminum hydride is dissolved in 100 ml. of anhydrous tetrahydrofuran at 0° C, under nitrogen, and then 0.0425 mole of bicyclo[2.2.1]hept-7-yl acetamide in 100 ml. of anhydrous tetrahydrofuran is added dropwise. The mixture is stirred for about 12 hours at room temperature and then about 10 ml. of water is carefully added to decompose excess lithium aluminum hydride (and complex). The mixture is then filtered and the filtrate then dried with potassium hydroxide pellets; filtered and the filtrate distilled, to remove solvent, affording 2-(bicyclo[2.2.1]hept-7-yl)ethylamine.

후처리

  1. customat 0° C
  2. filtrationThe mixture is then filtered
  3. dry with materialthe filtrate then dried with potassium hydroxide pellets
  4. filtrationfiltered
  5. distillationthe filtrate distilled
  6. customto remove solvent

출처 및 근거

ORD 기록
ord-b6774ea8d7b94674b29ebc7663e32a37
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04064258

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