Diethyl Ether → (4-Methylbicyclo[2.2.2]octan-1-yl)methanol

HRID 461990노트

반응식

HRID 461990 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)C.[CH3:12][C:13]12[CH2:20][CH2:19][C:16]([C:21](O)=[O:22])([CH2:17][CH2:18]1)[CH2:15][CH2:14]2.O1CCCC1>O.C(OCC)(=O)C>[OH:22][CH2:21][C:16]12[CH2:17][CH2:18][C:13]([CH3:12])([CH2:20][CH2:19]1)[CH2:14][CH2:15]2

참가 물질

7

반응물 4

HCID 3283Diethyl EtherHCID 8028TetrahydrofuranHCID 1365444-Methylbicyclo[2.2.2]octane-1-carboxylic acidHCID 21226445Aluminium lithium hydride2회

생성물 1

HCID 13227648(4-Methylbicyclo[2.2.2]octan-1-yl)methanol

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

0.0952 Mole of lithium aluminum hydride is dissolved in 200 ml. of anhydrous diethyl ether, under nitrogen, and cooled to 0° C. 0.0952 Mole of 4-methylbicyclo[2.2.2]oct-1-yl carboxylic acid in 100 ml. of tetrahydrofuran is added dropwise, then the mixture stirred for 30 minutes. Excess lithium aluminum hydride is decomposed by the cautious addition of ethyl acetate, followed by the careful addition of 10 ml. of water. The mixture is then filtered and the filtrate washed with ethyl ether, then dried over anhydrous magnesium sulfate and filtered. The solvent is then evaporated from the filtrate, under vacuum, affording 1-(hydroxymethyl)-4-methylbicyclo[2.2.2]octane.

후처리

  1. additionfollowed by the careful addition of 10 ml
  2. filtrationThe mixture is then filtered
  3. washthe filtrate washed with ethyl ether
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe solvent is then evaporated from the filtrate, under vacuum

출처 및 근거

ORD 기록
ord-f0bf4585fc164ba4b2f62705de1a3733
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04064258

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