Diethyl Ether → Tricyclo(3.3.1.13,7)decane-2-ethanamine

HRID 461997노트

반응식

HRID 461997 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)C.[CH:12]12[CH2:21][CH:16]3[CH2:17][CH:18]([CH2:20][CH:14]([CH2:15]3)[CH:13]1[CH2:22][C:23]#[N:24])[CH2:19]2>O>[CH:12]12[CH2:21][CH:16]3[CH2:17][CH:18]([CH2:20][CH:14]([CH2:15]3)[CH:13]1[CH2:22][CH2:23][NH2:24])[CH2:19]2

참가 물질

5

반응물 3

HCID 3283Diethyl Ether2회HCID 12571472HCID 12571472, 화합물HCID 21226445Aluminium lithium hydride

생성물 1

HCID 64411Tricyclo(3.3.1.13,7)decane-2-ethanamine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

0.051 Mole of lithium aluminum hydride is dissolved in 200 ml. of anhydrous ethyl ether at 0° C, under nitrogen. 0.0571 Mole of adamant-2-yl acetonitrile in 100 ml. of anhydrous ethyl ether is added dropwise with stirring and the mixture is allowed to warm to room temperature and stirred for one hour. 10 Ml. of water is added dropwise and the mixture then filtered. The filtrate is dried over potassium hydroxide pellets and then filtered. The filtrate is distilled to remove the solvent affording 2-(adamant-2-yl)ethylamine.

후처리

  1. customat 0° C
  2. stirringstirred for one hour
  3. filtrationthe mixture then filtered
  4. dry with materialThe filtrate is dried over potassium hydroxide pellets
  5. filtrationfiltered
  6. distillationThe filtrate is distilled
  7. customto remove the solvent

출처 및 근거

ORD 기록
ord-4e6c68a254ed46c19719c17aa1e90ab4
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04064258

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