Ethanethiol → 2-chloroethanethiophosphonic acid S-ethyl ester N-monoisopropylamide

HRID 462011노트

반응식

HRID 462011 반응식
[CH2:1]([SH:3])[CH3:2].C(N(CC)CC)C.[Cl-].[CH:12]([NH:15][P:16]([CH2:19][CH2:20][Cl:21])(=[O:18])[OH:17])([CH3:14])[CH3:13]>C1C=CC=CC=1>[CH:12]([NH-:15])([CH3:14])[CH3:13].[CH2:1]([S:3][P:16]([CH2:19][CH2:20][Cl:21])(=[O:17])[OH:18])[CH3:2]

참가 물질

5

반응물 3

HCID 6343EthanethiolHCID 8471TriethylamineHCID 867353082-chloroethanephosphonic acid N-monoisopropylamide chloride

생성물 1

HCID 867353102-chloroethanethiophosphonic acid S-ethyl ester N-monoisopropylamide

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

13 g (0.2 mole) ethylmercaptan and 20 g (0.2 mole) triethylamine are added to 41 g (0.2 mole) 2-chloroethanephosphonic acid N-monoisopropylamide chloride in 100 ml benzene. Stirring was afterwards effected for 2 hours at 40° C; the salts were then filtered off with suction, the reaction solution was washed with water, and drying with sodium sulfate was carried out. After the solvent had been drawn off, there remained behind a crystalline residue, m.p. 51° C, yield: 15 g (33%) 2-chloroethanethiophosphonic acid S-ethyl ester N-monoisopropylamide.

후처리

  1. filtrationthe salts were then filtered off with suction
  2. washthe reaction solution was washed with water
  3. dry with materialdrying with sodium sulfate

출처 및 근거

ORD 기록
ord-f7e0b7a378554beaa6617603c1906cbe
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065288

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