2-Pyridone → 3-(3-Chlorophenyl)-5-(4-chlorophenyl)-1-methylpiperidin-4-one

HRID 462015노트

반응식

HRID 462015 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:13](=[O:14])[C:12]([C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)=[CH:11][N:10]([CH3:22])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.N1C=CC=CC1=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CC(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13](=[O:14])[CH:12]([C:15]3[CH:16]=[CH:17][C:18]([Cl:21])=[CH:19][CH:20]=3)[CH2:11][N:10]([CH3:22])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 88712-PyridoneHCID 128792353-(3-Chlorophenyl)-5-(4-chlorophenyl)-1-methylpyridin-4(1H)-oneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 203170023-(3-Chlorophenyl)-5-(4-chlorophenyl)-1-methylpiperidin-4-one

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A 10 g. portion of 3-(3-chlorophenyl)-5-(4-chlorophenyl)-1-methyl-4(1H)-pyridinone was made from 33.6 g. of the corresponding 2-propanone by the procedures of Examples 1-3. The pyridinone was reduced with lithium aluminum hydride and the reaction mixture was separated by chromatography as described in the examples above. The products of Examples 15 and 16 were obtained as a mixture containing both, combined yield 2.1 g., m.p. 125.5°.

후처리

  1. customthe reaction mixture was separated by chromatography

출처 및 근거

ORD 기록
ord-558f29a58adc4b258d6bd1bcf92e38c8
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065290

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