Nordiazepam → Oxazepam

HRID 462039

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[CH:19]=1.[Cl:20][CH2:21][C:22]([O:24]C(=O)CCl)=[O:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH:9]([OH:23])[N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[CH:19]=1.[Cl:20][CH2:21][C:22]([O-:24])=[O:23]

참가 물질

반응물 2

HCID 2997Nordiazepam

HCID 10946Chloroacetic anhydride

생성물 2

HCID 4616Oxazepam

HCID 518964Chloroacetate

실험 절차

Following the procedure of the preceding paragraph react 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one, 4-oxide with chloroacetic anhydride to produce 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, chloroacetate.

출처 및 근거

ORD 기록: ord-2bc885ae146e437e83dfc7f6cfea4676
출처 데이터셋: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04065451

연결된 노트

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