3-Chloro-1,2-propanediol → 6-(2,3-Dihydroxy)propoxy-3,4-dihydrocarbostyril

HRID 462049노트

반응식

HRID 462049 반응식
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]2.[CH2:13]([OH:18])[CH:14]([OH:17])[CH2:15]Cl>>[OH:17][CH:14]([CH2:13][OH:18])[CH2:15][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]2

참가 물질

3

반응물 2

HCID 72903-Chloro-1,2-propanediolHCID 27740406-Hydroxy-3,4-dihydro-2(1H)-quinolinone

생성물 1

HCID 213903426-(2,3-Dihydroxy)propoxy-3,4-dihydrocarbostyril

실험 절차

In the same manner as described in Example 7, 6-hydroxy-3,4-dihydrocarbostyril was reacted with gylcerol α-monochlorohydrin to give 6-(2,3-dihydroxy)propoxy-3,4-dihydrocarbostyril as white needle-like crystals having a melting point of 190° - 192° C.

출처 및 근거

ORD 기록
ord-1054a4cc81d8474db4e03b26058bc4be
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065456

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