1,4-Dioxane → 2-[2-(2,2-Diethoxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

HRID 462231

반응식

HRID 462231 반응식
OCCN[N:5]1[NH:9][CH:8]=[C:7]([C:10]2[N:11]([CH3:18])[C:12]([N+:15]([O-:17])=[O:16])=[CH:13][N:14]=2)[S:6]1.[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH2:24])[CH3:20].O1CCOCC1>O>[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH:24][N:5]1[NH:9][CH:8]=[C:7]([C:10]2[N:11]([CH3:18])[C:12]([N+:15]([O-:17])=[O:16])=[CH:13][N:14]=2)[S:6]1)[CH3:20]

참가 물질

5

반응물 3

HCID 312751,4-DioxaneHCID 695242,2-DiethoxyethylamineHCID 213908472-[2-(Hydroxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

생성물 1

HCID 213908052-[2-(2,2-Diethoxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture composed 9.8 g. of 2-(2-chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole, (Example 16), 11.0 g. of 2,2-diethoxyethylamine, and 250 ml. of dioxane is stirred and heated on the steam bath for 12 hours. It is then diluted with 500 ml. of cold water, cooled, and the precipitated yellow solid collected and dried. Recrystallization from 505 aqueous ethanol gives the pure compound melting at 154°-155° C.

후처리

  1. temperatureheated on the steam bath for 12 hours
  2. additionIt is then diluted with 500 ml
  3. customthe precipitated yellow solid collected
  4. customdried
  5. customRecrystallization from 505 aqueous ethanol

출처 및 근거

ORD 기록
ord-6374fafd84ab42c4a03c9e00a0e91554
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065567

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