Piperidine → 2-(2-Piperidino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

HRID 462232

반응식

HRID 462232 반응식
O[CH2:2][CH2:3][NH:4][N:5]1[NH:9][CH:8]=[C:7]([C:10]2[N:11]([CH3:18])[C:12]([N+:15]([O-:17])=[O:16])=[CH:13][N:14]=2)[S:6]1.N1CC[CH2:22][CH2:21][CH2:20]1>O1CCOCC1>[N:4]1([N:5]2[NH:9][CH:8]=[C:7]([C:10]3[N:11]([CH3:18])[C:12]([N+:15]([O-:17])=[O:16])=[CH:13][N:14]=3)[S:6]2)[CH2:22][CH2:21][CH2:20][CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 213908472-[2-(Hydroxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

생성물 1

HCID 213908372-(2-Piperidino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture composed of 7.4 g. of 2-(2-chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole (Example 16), 6 g. of piperidine, and 200 ml. of dioxane is stirred at room temperture for 24 hours, and then taken to dryness under reduced pressure. The residue is shaken with 100 ml. of water and the insoluble portion collected and dried. Recrystallization from 150 ml. of 2-methoxyethanol gives 7.6 g. of the subject compound melting at 212°-213° C.

후처리

  1. customof water and the insoluble portion collected
  2. customdried
  3. customRecrystallization from 150 ml
  4. customof 2-methoxyethanol gives 7.6 g

출처 및 근거

ORD 기록
ord-5858bf4c46db476f87049c84178d167a
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065567

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