1-[3-(Dimethylamino)propyl]piperazine → 2-{2-[4-(3-Dimethylaminopropyl)-1-piperazinyl]-5-thiadiazolyl}-1-methyl-5-nitroimidazole

HRID 462236

반응식

HRID 462236 반응식
Cl[N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1.[CH3:16][N:17]([CH3:27])[CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>O1CCOCC1>[CH3:27][N:17]([CH3:16])[CH2:18][CH2:19][CH2:20][N:21]1[CH2:22][CH2:23][N:24]([N:2]2[NH:6][CH:5]=[C:4]([C:7]3[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=3)[S:3]2)[CH2:25][CH2:26]1

참가 물질

4

반응물 2

HCID 27362341-[3-(Dimethylamino)propyl]piperazineHCID 21390801HCID 21390801, 화합물

생성물 1

HCID 213908032-{2-[4-(3-Dimethylaminopropyl)-1-piperazinyl]-5-thiadiazolyl}-1-methyl-5-nitroimidazole

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of 2-(2-chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole in 200 ml. of dioxane is treated with 5.1 g. of 1-(3-dimethylaminopropyl)piperazine, and the mixture stirred at room temperature for 18 hours. The precipitate is collected, dissolved in 100 ml. of water, made alkaline with sodium hydroxide solution, and then extracted with 500 ml. of chloroform. The chloroform extract is dried and the solvent removed under reduced pressure. The yellow residue is recrystallized from 100 ml. of ethanol to give 2.9 g. of product, melting at 174°-175° C.

후처리

  1. customThe precipitate is collected
  2. dissolutiondissolved in 100 ml
  3. extractionextracted with 500 ml
  4. extractionThe chloroform extract
  5. customis dried
  6. customthe solvent removed under reduced pressure
  7. customThe yellow residue is recrystallized from 100 ml
  8. customof ethanol to give 2.9 g

출처 및 근거

ORD 기록
ord-c2bace9bd66849a0a94a28186d1478c3
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065567

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