Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Thiazol-2-yl)piperazine → 2-{2-[4-(2-Thiazolyl)-1-piperazinyl]-5-thiadiazolyl]-1-methyl-5-nitroimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Thiazol-2-yl)piperazine | HCID 911806 | — |
| 반응물 | 1-[3-(Dimethylamino)propyl]piperazine | HCID 2736234 | — |
| 반응물 | 2-{2-[4-(3-Dimethylaminopropyl)-1-piperazinyl]-5-thiadiazolyl}-1-methyl-5-nitroimidazole | HCID 21390803 | — |
| 생성물 | 2-{2-[4-(2-Thiazolyl)-1-piperazinyl]-5-thiadiazolyl]-1-methyl-5-nitroimidazole | HCID 21390853 | — |
반응 단계
The preparation of the subject compound is carried out essentially as described for the 2-[4-(3-dimethylaminopropyl)-1-piperazinyl] derivative (Example 35), an equivalent of 1-(2-thiazolyl)piperazine replacing the 1-(3-dimethylaminopropyl)piperazine. After recrystallization from 2-methoxyethanol, the pure compound melts at 297°-300° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04065567 |
| 출처 데이터셋 | uspto-grants-1977_12 |
| ORD ID | ord-10dfc038fa9d47f89d1562cb38168a32 |
| 출처 메모 | uspto-grants-1977_12 |