참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2,4-Dichlorobenzoic Acid | HCID 5787 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 촉매 | Sulfur | HCID 5362487 | — |
| 용매 | Chlorosulfonic acid | HCID 24638 | — |
| 생성물 | 5-Bromo-2,4-dichlorobenzoic acid | HCID 21862565 | 187.5% |
반응 단계
To a solution of 2,4-dichlorobenzoic acid (compound 80, 25.0 g, 131 mmol) in chlorosulfonic acid (100 mL) was added bromine (3.4 mL, 65 mmol) and sulfur (0.20 g, 6.6 mmol). The reaction mixture was stirred at 70° C. overnight and then cooled to ambient temperature. The reaction mixture was poured into iced water. The resulting solid was isolated by filtration and dried in vacuo to yield title compound (32.9 g, 93%) as pale brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08541380B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-541340427c5d4696b208240ea8e76d24 |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
