Benzyl Alcohol → Benzyl phenylacetate

HRID 462306

반응식

HRID 462306 반응식
[C:1]1([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:11](O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.C1(C)C=CC=CC=1>O>[C:1]1([CH2:7][C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 4

HCID 244Benzyl AlcoholHCID 999Phenylacetic AcidHCID 1140TolueneHCID 6101p-Toluenesulfonic acid

생성물 1

HCID 60999Benzyl phenylacetate수율 83%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of phenyl acetic acid (27.2 g.), benzyl alcohol (21.6 g.) and p-toluenesulfonic acid (380 mg.) in 100 ml. of toluene was heated under reflux under a Dean-Stark trap until the theoretical (3.6 ml.) quantity of water had been collected. On cooling, the solution was washed with dilute NaHCO3 and saturated NaCl and solvent was removed in vacuo.. The resulting oil was distilled at 125°-129° (0.4 torr)1 to give pure benzyl phenylacetate, 37.7 g. (83% yield). ##STR230##

후처리

  1. customhad been collected
  2. temperatureOn cooling
  3. washthe solution was washed with dilute NaHCO3 and saturated NaCl and solvent
  4. customwas removed in vacuo
  5. distillationThe resulting oil was distilled at 125°-129° (0.4 torr)1

출처 및 근거

ORD 기록
ord-b6015e5e9c4f4828894d6a1ff668db79
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065623

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