Hydrogen Sulfide → HCID 178523349, 화합물

HRID 462398

반응식

HRID 462398 반응식
C(N(CC)CC)C.ClC(OCC(C)C)=O.[CH2:16]([O:23][C:24]([NH:26][CH2:27][CH2:28][CH2:29][C:30]([OH:32])=O)=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.S.[S:34](=O)(=O)(O)O>C(Cl)Cl>[CH2:16]([O:23][C:24]([NH:26][CH2:27][CH2:28][CH2:29][C:30]([OH:32])=[S:34])=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

7

반응물 5

HCID 402Hydrogen SulfideHCID 1118Sulfuric AcidHCID 8471TriethylamineHCID 211844-(((Benzyloxy)carbonyl)amino)butanoic acidHCID 62365Isobutyl chloroformate

생성물 1

HCID 178523349HCID 178523349, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2.2 g (20 mmol) of triethylamine and a solution of 1.4 ml (10 mmol) of isobutyl chloroformate in 20 ml of dry methylene chloride are added dropwise, in succession, to a solution, cooled to -10°, of 2.37 g (10 mmol) of 4-benzyloxycarbonylaminobutyric acid in 50 ml of dry methylene chloride. The reaction mixture is stirred for one hour at -10° and then a strong current of hydrogen sulphide is passed through for 11/2 hours. After warming to room temperature, the mixture is cooled again and acidified with 2N sulphuric acid. The organic phase is separated, dried and concentrated in vacuo. The 4-benzyloxycarbonylaminothiobutyric acid obtained can be used without further purification.

후처리

  1. custom2 hours
  2. temperaturethe mixture is cooled again
  3. customThe organic phase is separated
  4. customdried
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-3f676cbf60284747a21171f1af3bf556
출처 데이터셋
uspto-grants-1985_05
특허 번호
US04515717

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