Diethyl Ether → N,N-Dimethyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarboxamide

HRID 4625노트

반응식

HRID 4625 반응식
[CH2:1]([N:3]([CH2:6]C)[CH2:4]C)C.[N:8]1([CH2:14][C:15]2[CH:16]=[C:17]([CH:27]=[CH:28][CH:29]=2)[O:18][CH2:19][CH2:20][CH2:21][NH:22][C:23]([NH:25][NH2:26])=[O:24])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.CC[O:32]CC>>[CH3:1][N:3]([CH3:6])[C:4]([NH:26][NH:25][C:23]([NH:22][CH2:21][CH2:20][CH2:19][O:18][C:17]1[CH:27]=[CH:28][CH:29]=[C:15]([CH2:14][N:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH:16]=1)=[O:24])=[O:32]

참가 물질

4

반응물 3

HCID 3283Diethyl EtherHCID 8471TriethylamineHCID 13657330N-(3-{3-[(Piperidin-1-yl)methyl]phenoxy}propyl)hydrazinecarboxamide

생성물 1

HCID 13657354N,N-Dimethyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarboxamide

실험 절차

0.6 ml (4 mmol) of triethylamine and 0.4 ml (4 mmol) of N,N-dimethyl-carbamide chloride are added to 1.2 g (4 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carboxamide in 20 ml of ether and the reaction mixture is stirred for 12 hours. Solid triethylammonium chloride is filtered off and the filtrate is concentrated by evaporation under vacuum.

후처리

  1. filtrationSolid triethylammonium chloride is filtered off
  2. concentrationthe filtrate is concentrated by evaporation under vacuum

출처 및 근거

ORD 기록
ord-d528eaedefc846aebb42fe733e14626e
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727081

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