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Acetic Acid → 6-[(E)-3-tert-butyldimethylsilyloxy-4-phenoxybut-1-enyl]-3-(1-hydroxy-4-methoxycarbonylbut-1-yl)bicyclo[3,3,0]octan-2-one

HRID 462801
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HRID 462801 반응식
[Si:1]([O:8][CH:9]([CH2:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)/[CH:10]=[CH:11]/[CH:12]1[CH2:19][CH2:18][CH:17]2[CH:13]1[CH2:14][CH2:15][C:16]2=[O:20])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].C[Si]([N-][Si](C)(C)C)(C)C.[Li+].[CH3:39][O:40][C:41]([CH2:43][CH2:44][CH2:45][CH:46]=[O:47])=[O:42].C(O)(=O)C>O1CCCC1.C(OCC)C.O>[Si:1]([O:8][CH:9]([CH2:21][O:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)/[CH:10]=[CH:11]/[CH:12]1[CH2:19][CH2:18][CH:17]2[CH:13]1[CH2:14][CH:15]([CH:46]([OH:47])[CH2:45][CH2:44][CH2:43][C:41]([O:40][CH3:39])=[O:42])[C:16]2=[O:20])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

8

반응물 4

HCID 176Acetic AcidHCID 554053Pentanoic acid, 5-oxo-, methyl esterHCID 2733832Lithium hexamethyldisilazaneHCID 20397195(E)-2-(3-tert-butyldimethylsilyloxy-4-phenoxybut-1-enyl)bicyclo[3,3,0]octan-6-one

생성물 1

HCID 203972146-[(E)-3-tert-butyldimethylsilyloxy-4-phenoxybut-1-enyl]-3-(1-hydroxy-4-methoxycarbonylbut-1-yl)bicyclo[3,3,0]octan-2-one수율 47.3%

시약·촉매·용매 3

HCID 962Water용매HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
-70 °C

실험 절차

A stirred solution of (E)-2-(3-tert-butyldimethylsilyloxy-4-phenoxybut-1-enyl)bicyclo[3,3,0]octan-6-one (75 mg), prepared as described in Reference Example 46 and in the form of (±)-(E)-2β-(3β-tert-butyldimethylsilyloxy-4-phenoxybut-1-enyl)bicyclo[3,3,0]octan-6-one, in dry tetrahydrofuran (2.55 ml) was cooled to -70° C. under an atmosphere of argon and treated with a solution of lithium bis(trimethylsilyl)amide in tetrahydrofuran (1M; 0.204 ml), and the mixture was stirred at -70° C. for 10 minutes. The mixture was then treated with 4-methoxycarbonylbutanal (44 mg) and stirred for a further period of 150 minutes at -70° C. The mixture was then treated with a solution of glacial acetic acid (0.019 ml) in diethyl ether (0.17 ml) and allowed to warm to the ambient temperature. The mixture was treated with water (25 ml) and extracted with ethyl acetate. The extract was washed with saturated aqueous sodium bicarbonate solution, and with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulphate, and concentrated under reduced pressure. The residual oil was subjected to medium pressure, short column chromatography on silica gel, eluting with a mixture of ethyl acetate and hexane (1:2 v/v), to give 6-[(E)-3-tert-butyldimethylsilyloxy-4-phenoxybut-1-enyl]-3-(1-hydroxy-4-methoxycarbonylbut-1-yl)bicyclo[3,3,0]octan-2-one (47 mg), in the form of (±)-6β-[(E)-3β-tert-butyldimethylsilyloxy-4-phenoxybut-1-enyl]-3-(1-hydroxy-4-methoxycarbonylbut-1-yl)bicyclo[3,3,0]octan-2-one.

후처리

  1. stirringstirred for a further period of 150 minutes at -70° C
  2. temperatureto warm to the ambient temperature
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed with saturated aqueous sodium bicarbonate solution
  5. dry with materialwith saturated aqueous sodium chloride solution, dried over anhydrous sodium sulphate
  6. concentrationconcentrated under reduced pressure
  7. washeluting with a mixture of ethyl acetate and hexane (1:2 v/v)

출처 및 근거

ORD 기록
ord-0459a8ac3b12418c87674bc3732b0590
출처 데이터셋
uspto-grants-1985_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04517202

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