Iodine → 2,3-Dichloro-5-iodopyridine

반응식

[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Li])=[CH:4][N:3]=1.[I:10]I>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([I:10])=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 807Iodine

HCID 178506762HCID 178506762, 화합물

생성물 1

HCID 218928742,3-Dichloro-5-iodopyridine

실험 절차

Briefly, in accordance with the present invention, 2,3-dichloro-5-iodopyridine is prepared by lithiating 5-bromo-2,3-dichloropyridine at a reduced temperature to form 2,3-dichloro-5-lithiopyridine. The 2,3-dichloro-5-lithiopyridine is then reacted with I2 at a reduced temperature to form 2,3-dichloro-5-iodopyridine. The resulting product is then extracted and recovered. 2,3-Dichloro-5-iodopyridine is in the form of a white solid and has a melting point of from 56.5° C. to 57.5° C.

출처 및 근거

ORD 기록: ord-bec383ef62d84f5d9dae01d4b115ad24
출처 데이터셋: uspto-grants-1985_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04517368

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