Iodine → 2,3-Dichloro-5-iodopyridine

HRID 462816노트

반응식

HRID 462816 반응식
C([Li])CCC.[I:6]I.Br[C:9]1[CH:10]=[C:11]([Cl:16])[C:12]([Cl:15])=[N:13][CH:14]=1>C(OCC)C.CCCCCC>[Cl:15][C:12]1[C:11]([Cl:16])=[CH:10][C:9]([I:6])=[CH:14][N:13]=1

참가 물질

6

반응물 3

HCID 807IodineHCID 127477605-Bromo-2,3-dichloropyridineHCID 178418339Butyllithium

생성물 1

HCID 218928742,3-Dichloro-5-iodopyridine

시약·촉매·용매 2

HCID 3283Diethyl Ether용매2회HCID 8058Hexane용매

반응 조건

온도
-78 °C

실험 절차

In one embodiment of the present invention, 5-bromo-2,3-dichloropyridine is dissolved in ethyl ether and cooled to about -78° C. A slight excess molar quantity of n-butyl lithium, dissolved in hexane, is slowly added to the reaction mixture with mild agitation. After about 0.5 hour of stirring, a slight excess molar quantity of I2, dissolved in ethyl ether, is added to reaction mixture with mild agitation. After about 0.5 hour of stirring, the reaction mixture is allowed to warm to room temperature and the 2,3-dichloro-5-iodopyridine is isolated employing standard separatory and purification techniques.

후처리

  1. additionis slowly added to the reaction mixture with mild agitation
  2. additionis added to reaction mixture with mild agitation
  3. stirringAfter about 0.5 hour of stirring
  4. temperatureto warm to room temperature

출처 및 근거

ORD 기록
ord-b1b825a7855043d992d3ed1e62d81722
출처 데이터셋
uspto-grants-1985_05
특허 번호
US04517368

반응 노트

불러오는 중…