Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 2,4-Difluorobenzenesulfonyl Chloride | HCID 2734273 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide | HCID 25038904 | — |
반응 단계
To a slurry of 2-aminothiazole (15.08 g, 0.1506 mol) in methylene chloride (100 mL) and pyridine (24 mL, 0.30 mol) was added dropwise over 20 minutes a solution of 2,4-difluorobenzenesulfonyl chloride (10 mL, 0.07 mol) in 10 mL of methylene chloride. After stirring at room temperature for 48 hours the reaction was concentrated and purified by flash column chromatography eluting with hexane/ethyl acetate. LCMS Rt=1.21 minutes MS m/z 277 [MH]+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541588B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-b083043d358544dcbd3734bbd645a5dc |
| 출처 메모 | uspto-grants-2013_09 |