참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Glutaric Acid | HCID 743 | — |
| 반응물 | Glyoxylylspermidine | HCID 133564 | — |
| 반응물 | HCID 178478612 | HCID 178478612 | — |
| 반응물 | HCID 178479441 | HCID 178479441 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 178512828 | HCID 178512828 | 37.1% |
반응 단계
A mixture of 92.4 mg (0.48 mmole) of 5-guanidinopentanamide hydrochloride, 166.5 mg (0.57 mmole) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 62.8 mg (0.48 mmole) of glutaric acid and 0.1 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, 5 ml of water was added to the reaction mixture which was then purified in a manner similar to that in Example 1 using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 82.5 mg (37.1% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(5-guanidinopentanamido)-2-hydroxyethanamide trihydrochloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04518532 |
|---|
| 출처 데이터셋 | uspto-grants-1985_05 |
|---|
| ORD ID | ord-7ecb292195b241efa5d2b94bfa3b0af0 |
|---|
| 출처 메모 | uspto-grants-1985_05 |
|---|
