참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Glutaric Acid | HCID 743 | — |
| 반응물 | Glyoxylylspermidine | HCID 133564 | — |
| 반응물 | HCID 178478611 | HCID 178478611 | — |
| 반응물 | HCID 178479436 | HCID 178479436 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 178512817 | HCID 178512817 | 44% |
반응 단계
A mixture of 446 mg (2.14 mmoles) of 6-guanidinohexanamide hydrochloride, 750 mg (2.57 mmoles) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 283 mg (2.14 mmoles) of glutaric acid and 0.45 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, 5 ml of water was added to the reaction mixture and the resulting mixture was purified in a manner similar to that in Example 1, using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 459 mg (44% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(6-guanidinohexanamido)-2-hydroxyethanamide trihydrochloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04518532 |
|---|
| 출처 데이터셋 | uspto-grants-1985_05 |
|---|
| ORD ID | ord-5428e93f3522409ab46bd8ae87e26d73 |
|---|
| 출처 메모 | uspto-grants-1985_05 |
|---|
