Glutaric Acid → HCID 178512808, 화합물

HRID 462910

반응식

HRID 462910 반응식
Cl.N(CCCCCCC(N)=O)C(N)=N.Cl.Cl.NCCCNCCCCNC(=O)C(O)O.C(O)(=O)CCCC(O)=O.Cl.Cl.Cl.[NH2:44][CH2:45][CH2:46][CH2:47][NH:48][CH2:49][CH2:50][CH2:51][CH2:52][NH:53][C:54](=[O:70])[CH:55]([NH:57][C:58](=[O:69])[CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][NH:65][C:66]([NH2:68])=[NH:67])[OH:56]>O>[NH2:44][CH2:45][CH2:46][CH2:47][NH:48][CH2:49][CH2:50][CH2:51][CH2:52][NH:53][C:54](=[O:70])[CH:55]([NH:57][C:58](=[O:69])[CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][NH:65][C:66]([NH2:68])=[NH:67])[OH:56]

참가 물질

6

반응물 4

HCID 743Glutaric AcidHCID 133564GlyoxylylspermidineHCID 178478610HCID 178478610, 화합물HCID 178479429HCID 178479429, 화합물

생성물 1

HCID 178512808HCID 178512808, 화합물수율 39%

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
60 °C

실험 절차

A mixture of 360 mg (1.62 mmoles) of 7-guanidinoheptanamide hydrochloride, 568 mg (1.94 mmoles) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 214 mg (1.62 mmoles) of glutaric acid and 0.36 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, 5 ml of water was added to the reaction mixture and the resulting mixture was purified in a manner similar to that in Example 1, using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 317 mg (39% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(7-guanidinoheptanamido)-2-hydroxyethanamide trihydrochloride.

후처리

  1. additionwas added to the reaction mixture
  2. customthe resulting mixture was purified in a manner similar to that in Example 1

출처 및 근거

ORD 기록
ord-89bca08c32784ea2b7a91ac5492d07d9
출처 데이터셋
uspto-grants-1985_05
특허 번호
US04518532

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