Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Gamma-Aminobutyric Acid → 4-(((Benzyloxy)carbonyl)amino)butanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Gamma-Aminobutyric Acid | HCID 119 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-(((Benzyloxy)carbonyl)amino)butanoic acid | HCID 21184 | — |
반응 단계
A solution of 5.16 g (0.103 mmol) of benzyl chloroformate in 100 ml of dry dioxan is added dropwise over a period of 30 minutes to a solution of 10.60 g (0.1 mmol) of 4-aminobutyric acid in 300 ml of 1N sodium hydroxide solution in an ice bath. The reaction mixture is stirred for 30 minutes at room temperature, acidified with 2N hydrochloric acid and extracted with methylene chloride. The organic phase is dried with sodium sulphate and concentrated in vacuo. The 4-benzyloxycarbonylaminobutyric acid obtained is recrystallised from ethyl acetate, methylene chloride and hexane; melting point 61°-62°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04518533 |
| 출처 데이터셋 | uspto-grants-1985_05 |
| ORD ID | ord-ea61c5728c944f2aa507a1acd9a10a35 |
| 출처 메모 | uspto-grants-1985_05 |