Acetyl chloride → 2-(N-Acetyl-piperazino)-8-benzylthio-4-morpholino-pyrimido-[5,4-d]-pyrimidine

HRID 462945

반응식

HRID 462945 반응식
[CH2:1]([S:8][C:9]1[C:14]2[N:15]=[C:16]([N:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31](Cl)(=[O:33])[CH3:32]>CC(C)=O>[C:31]([N:28]1[CH2:27][CH2:26][N:25]([C:16]2[N:17]=[C:18]([N:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)[C:13]3[N:12]=[CH:11][N:10]=[C:9]([S:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[C:14]=3[N:15]=2)[CH2:30][CH2:29]1)(=[O:33])[CH3:32]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 132466RX-RA 69

생성물 1

HCID 201501312-(N-Acetyl-piperazino)-8-benzylthio-4-morpholino-pyrimido-[5,4-d]-pyrimidine

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A suspension of 2.1 gm (0.005 mol) of 8-benzylthio-4-morpholino-2-piperazino-pyrimido-[5,4-d]-pyrimidine (m.p.: 191°-193° C.) in 150 ml of acetone was refluxed for 30 minutes after addition of 0.8 gm (0.01 mol) of acetyl chloride. The solvent was then evaporated in vacuo, and the residue was taken up in approximately 200 ml of water. The reaction product was suction-filtered off, washed with water and dried.

후처리

  1. temperaturewas refluxed for 30 minutes
  2. customThe solvent was then evaporated in vacuo
  3. filtrationThe reaction product was suction-filtered off
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-03e252ba4b3c4480bdfd09269861dd62
출처 데이터셋
uspto-grants-1985_05
특허 번호
US04518596

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