Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Methoxy-2-nitrobenzaldehyde → (2-Amino-5-methoxyphenyl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Methoxy-2-nitrobenzaldehyde | HCID 230371 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (2-Amino-5-methoxyphenyl)methanol | HCID 13756678 | — |
반응 단계
A quantity of 181.2 gm (1 mol) of 5-methoxy-2-nitrobenzaldehyde (prepared by methylation of 2-nitro-5-hydroxy-benzaldehyde with methyl iodide/potassium tert.-butoxide in dimethylsulfoxide) is dissolved in 1.8 liters of methanol, mixed with 50 gm of Raney nickel, and hydrogenated at ambient temperature and at 5 bar. After ten hours, the hydrogen uptake has ended. The catalyst is removed by suction filtration, and the methanol is distilled off.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04518597 |
| 출처 데이터셋 | uspto-grants-1985_05 |
| ORD ID | ord-03aee2ce438b454aa75f4a46a9749cfa |
| 출처 메모 | uspto-grants-1985_05 |