Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4'-(Trifluoromethyl)-4-biphenylcarbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | n-Butyl lithium | HCID 61028 | — |
| 반응물 | 4-Bromo-4'-(trifluoromethyl)biphenyl | HCID 12712349 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 4'-(Trifluoromethyl)-4-biphenylcarbaldehyde | HCID 2782712 | — |
반응 단계
N-Butyllitium in hexane (95 ml, 1.55M) was added dropwise to 4-Bromo-4'-trifluoromethylbiphenyl (40 g) in 250 ml of THF under N2 at -70° C. After addition the mixture was stirred for a further 10 mins and then dry dimethylformamide (19.49) in a solution of dry tetrahydrofuran (100 ml) was added dropwise. The mixture was then allowed to warm to room temperature in the absence of coolant. After stirring for 1.5 hours water was added and the mixture extracted with ether. The water washed and dried extracts were evaporated to give p-(4-trifluoromethylphenyl)benzaldehyde (34.5 g) m.p. 70°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04520007 |
| 출처 데이터셋 | uspto-grants-1985_05 |
| ORD ID | ord-9d36cafe6e454d688a6364df5c155b1a |
| 출처 메모 | uspto-grants-1985_05 |