Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N-[4-[3-(1-piperidinylmethyl)phenoxy]-2-butenyl]-1,3,4-thiadiazole-2,5-diamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Amino-5-bromo-1,3,4-thiadiazole | HCID 3650883 | — |
| 반응물 | 4-[3-(1-Piperidinylmethyl)phenoxy]2-butene-1-amine | HCID 54432280 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-[4-[3-(1-piperidinylmethyl)phenoxy]-2-butenyl]-1,3,4-thiadiazole-2,5-diamine | HCID 54123024 | — |
반응 단계
0.6 g (2.3 mmol) of 4-[3-(1-piperidinylmethyl)phenoxy]2-butene-1-amine, 0.35 ml of triethylamine and 0.42 g (2.3 mmol) of 5-bromo-1,3,4-thiadiazole-2-amin are heated under reflux in 20 ml of THF for 3 hours. Solid triethylammonium bromide is filtered off, the filtrate is concentrated by evaporation and the oily residue is purified by preparative layer chromatography.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04727081 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-8eb4fc42e2804d748fd87ba8aac6a162 |
| 출처 메모 | uspto-grants-1988_02 |