Triethylamine → N-[4-[3-(1-piperidinylmethyl)phenoxy]-2-butenyl]-1,3,4-thiadiazole-2,5-diamine

HRID 4636

반응식

HRID 4636 반응식
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:17]=[CH:18][CH:19]=2)[O:11][CH2:12][CH:13]=[CH:14][CH2:15][NH2:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.Br[C:28]1[S:32][C:31]([NH2:33])=[N:30][N:29]=1>C1COCC1>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:17]=[CH:18][CH:19]=2)[O:11][CH2:12][CH:13]=[CH:14][CH2:15][NH:16][C:28]2[S:32][C:31]([NH2:33])=[N:30][N:29]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 36508832-Amino-5-bromo-1,3,4-thiadiazoleHCID 544322804-[3-(1-Piperidinylmethyl)phenoxy]2-butene-1-amine

생성물 1

HCID 54123024N-[4-[3-(1-piperidinylmethyl)phenoxy]-2-butenyl]-1,3,4-thiadiazole-2,5-diamine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

0.6 g (2.3 mmol) of 4-[3-(1-piperidinylmethyl)phenoxy]2-butene-1-amine, 0.35 ml of triethylamine and 0.42 g (2.3 mmol) of 5-bromo-1,3,4-thiadiazole-2-amin are heated under reflux in 20 ml of THF for 3 hours. Solid triethylammonium bromide is filtered off, the filtrate is concentrated by evaporation and the oily residue is purified by preparative layer chromatography.

후처리

  1. filtrationSolid triethylammonium bromide is filtered off
  2. concentrationthe filtrate is concentrated by evaporation
  3. customthe oily residue is purified by preparative layer chromatography

출처 및 근거

ORD 기록
ord-8eb4fc42e2804d748fd87ba8aac6a162
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727081

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