참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Benzocaine | HCID 2337 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(Methylsulfonamido)benzoic acid | HCID 250653 | — |
반응 단계
To 215.2 g (2.72 mole) of pyridine in 1250 ml of dichloromethane is added 238 g (1.44 mole) of ethyl 4-aminobenzoate. After cooling to 0° C., a solution of 177.6 g (1.55 mole) of methanesulfonyl chloride in 250 ml of dichloromethane is added with stirring. Upon completion of the addition, the ice bath is removed and the reaction is stirred for one hour at room temperature.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04544654 |
|---|
| 출처 데이터셋 | uspto-grants-1985_10 |
|---|
| ORD ID | ord-98f76ec3828f43fabcd0c535838e6578 |
|---|
| 출처 메모 | uspto-grants-1985_10 |
|---|
