Pyridine → 4-(Methylsulfonamido)benzoic acid

HRID 463671

반응식

HRID 463671 반응식
N1C=CC=CC=1.[NH2:7][C:8]1[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=1.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>ClCCl>[CH3:19][S:20]([NH:7][C:8]1[CH:18]=[CH:17][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1)(=[O:22])=[O:21]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 2337BenzocaineHCID 31297Methanesulfonyl chloride

생성물 1

HCID 2506534-(Methylsulfonamido)benzoic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

To 215.2 g (2.72 mole) of pyridine in 1250 ml of dichloromethane is added 238 g (1.44 mole) of ethyl 4-aminobenzoate. After cooling to 0° C., a solution of 177.6 g (1.55 mole) of methanesulfonyl chloride in 250 ml of dichloromethane is added with stirring. Upon completion of the addition, the ice bath is removed and the reaction is stirred for one hour at room temperature.

후처리

  1. additionUpon completion of the addition
  2. customthe ice bath is removed
  3. stirringthe reaction is stirred for one hour at room temperature

출처 및 근거

ORD 기록
ord-98f76ec3828f43fabcd0c535838e6578
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04544654

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