9-Chloroacridine → HCID 178419977, 화합물

HRID 463685노트

반응식

HRID 463685 반응식
Cl[C:2]1[C:3]2[C:8]([N:9]=[C:10]3[C:15]=1[CH:14]=[CH:13][CH:12]=[CH:11]3)=[CH:7][CH:6]=[CH:5][CH:4]=2.Br.[NH:17]([C:19]1[S:20][CH2:21][CH2:22][N:23]=1)[NH2:18].C([O-])(=O)C.[Na+]>C(O)C>[S:20]1[CH2:21][CH2:22][NH:23][C:19]1=[N:17][N:18]=[C:2]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=2[NH:9][C:10]2[C:15]1=[CH:14][CH:13]=[CH:12][CH:11]=2

참가 물질

5

반응물 3

HCID 710139-ChloroacridineHCID 517045Sodium AcetateHCID 27743032-Thiazolidinone, hydrazone, hydrobromide

생성물 1

HCID 178419977HCID 178419977, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.0 g of 9-chloroacridine, 0.926 g of 2-hydrazino-2-thiazoline hydrobromide and 0.767 g of anhydrous sodium acetate are dissolved in 100 ml of dry ethanol, heated to boiling under reflux for 2 hours and the red solution is then evaporated in vacuo. The residue is treated with water and the crystalline mass is filtered under suction. After recrystallization from ethanol, there is obtained 9-acridanone (2-thiazolidinylidene)hydrazone of melting point 212°-216° (decomposition).

후처리

  1. temperatureheated
  2. temperatureunder reflux for 2 hours
  3. customthe red solution is then evaporated in vacuo
  4. additionThe residue is treated with water
  5. filtrationthe crystalline mass is filtered under suction
  6. customAfter recrystallization from ethanol

출처 및 근거

ORD 기록
ord-c3605f5043f3452c992a8c5d1410e2d7
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04544659

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