Thionyl Chloride → 2-(2,6-Dichlorophenyl)acetyl chloride

HRID 463778노트

반응식

HRID 463778 반응식
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[C:7]=1[CH2:13][C:14]([OH:16])=O>C1(C)C=CC=CC=1>[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[C:7]=1[CH2:13][C:14]([Cl:3])=[O:16]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 810582,6-Dichlorophenylacetic acid

생성물 1

HCID 27581482-(2,6-Dichlorophenyl)acetyl chloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

30.93 g of thionyl chloride are added dropwise to a warmed, mechanically stirred mixture of 45.12 g of 2,6-dichlorophenylacetic acid in 125 ml of toluene. The reaction mixture is then maintained at reflux for 5 hrs and cooled overnight at RT. The reaction mixture is concentrated in vacuo and the concentrate dissolved in hot petroleum ether and the solids filtered. The filtrate is concentrated in vacuo to give a dark amber liquid, which is distilled to give a clear pinkish liquid.

후처리

  1. temperatureThe reaction mixture is then maintained
  2. temperatureat reflux for 5 hrs
  3. concentrationThe reaction mixture is concentrated in vacuo
  4. dissolutionthe concentrate dissolved in hot petroleum ether
  5. filtrationthe solids filtered
  6. concentrationThe filtrate is concentrated in vacuo
  7. customto give a dark amber liquid, which
  8. distillationis distilled
  9. customto give a clear pinkish liquid

출처 및 근거

ORD 기록
ord-9c6f3cc32d0b4d0190c16567badbd980
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04544670

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