Water → HCID 13491698, 화합물

HRID 463797노트

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HRID 463797 반응식
[CH3:1][C:2]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[CH2:10](N(CC)CC)[CH3:11].C(Br)C.O>C1C=CC=CC=1>[CH2:10]([NH:4][C:3]1[CH:5]=[CH:6][CH:7]=[C:8]([Cl:9])[C:2]=1[CH3:1])[CH3:11]

참가 물질

6

반응물 4

HCID 962WaterHCID 6332Ethyl BromideHCID 68943-Chloro-2-methylanilineHCID 8471Triethylamine

생성물 1

HCID 13491698HCID 13491698, 화합물

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

In 100 ml of benzene is dissolved 14 g of 2-methyl-3-chloroaniline obtained in Reference Example 1 and, after adding 12 g of triethylamine, 13 g of ethyl bromide is added to the solution to conduct the reaction under reflux of benzene for 3 hours. After the completion of the reaction, the mixture is cooled to room temperature and shaken with 200 ml of water. The benzene layer is separated, dried over anhydrous magnesium sulfate, and concentrated. Distillation of the residue results in 12 g of N-ethyl-2-methyl-chloroaniline as the fraction of 125°-126° C./10 mmHg.

후처리

  1. customobtained in Reference Example 1
  2. additionis added to the solution
  3. customthe reaction
  4. customAfter the completion of the reaction
  5. customThe benzene layer is separated
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated
  8. distillationDistillation of the residue
  9. customresults in 12 g of N-ethyl-2-methyl-chloroaniline as the fraction of 125°-126° C./10 mmHg

출처 및 근거

ORD 기록
ord-a609d273a363402e9668b69a7fb72c5d
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04544747

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