Isopropylamine → HCID 13458391, 화합물

HRID 464019

반응식

HRID 464019 반응식
[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:8]([C:9](=[O:12])[CH2:10]Cl)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].O1CCOCC1.[CH:21]([NH2:24])([CH3:23])[CH3:22]>O>[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:8]([C:9](=[O:12])[CH2:10][NH:24][CH:21]([CH3:23])[CH3:22])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6363IsopropylamineHCID 88054'-Chloroacetyl(acetanilide)HCID 312751,4-Dioxane

생성물 1

HCID 13458391HCID 13458391, 화합물수율 89.6%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

In a reactor, 21 g (0.1 mol) of 4-acetylaminophenacyl chloride are introduced into a mixture comprising 100 ml of dioxane, 26 ml (0.3 mol) of isopropylamine and 20 ml of water. The reaction medium is stirred at 30°-40° C. for 2 hours. After the addition of 500 ml of iced water, a precipitate is collected, washed and dried. Recrystallization from ethyl acetate gives 21 g of N-(4-acetylaminophenacyl)isopropylamine, which is in the form of a white powder. Melting point (inst.)=156° C.

후처리

  1. customa precipitate is collected
  2. washwashed
  3. customdried
  4. customRecrystallization from ethyl acetate

출처 및 근거

ORD 기록
ord-4808f652adcb49a78b550fd4286098fc
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04545996

연결된 노트

불러오는 중…