2-Hydrazinoethanol → 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carbonitrile
반응식
C(O[CH:4]=[C:5]([C:8]#[N:9])[C:6]#[N:7])C.[OH:10][CH2:11][CH2:12][NH:13][NH2:14]>C(O)C>[NH2:9][C:8]1[N:13]([CH2:12][CH2:11][OH:10])[N:14]=[CH:4][C:5]=1[C:6]#[N:7]참가 물질
4
실험 절차
A procedure analogous to that described in Example 1 was followed except 20.0 g (164 mM) of ethoxymethylene malononitrile in 250 ml of warm ethanol were added to 13.4 ml (15.0 g, 197 mM) of 2-hydroxyethylhydrazine in 30 ml of ethanol maintained at 45°-50°. Following completion of the reaction and subsequent cooling of the mixture, the crystalline product was removed by filtration, and washed with ether to afford 20.5 g (82%) of the title compound: mp, 160°-161°: tlc, Rf =0.28, silica gel, ethyl acetate (100%).
후처리
- temperaturemaintained at 45°-50°
- customcompletion of the reaction
- temperaturesubsequent cooling of the mixture
- customthe crystalline product was removed by filtration
- washwashed with ether
출처 및 근거
- ORD 기록
- ord-6f8781c3366d43df940ae03eed571603
- 출처 데이터셋
- uspto-grants-1985_10
- 특허 번호
- US04546104
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