참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Amino-4-methoxy-6-methyl-1,3,5-triazine | HCID 15466 | — |
| 반응물 | Benzoic acid, 2-(chlorosulfonyl)-, methyl ester | HCID 117830 | — |
| 반응물 | Sodium Cyanate | HCID 517096 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 용매 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | Metsulfuron-methyl | HCID 52999 | 55% |
반응 단계
A slurry of 10.0 grams (0.042 moles) of 2-carbomethoxybenzenesulfonyl chloride, 5.0 grams (0.0357 moles) 4-methoxy-6-methyl-1,3,5-triazin-2-amine and 6.0 grams (0.092 moles) sodium cyanate in 60 ml N-methylpyrrolidinone was stirred 2 hours at 80° C. The reaction was cooled to 25° C., diluted with 200 ml saturated sodium bicarbonate solution, and filtered. The filtrate was acidified with dilute hydrochloric acid and the product was collected by filtration and dried to give the title compound in 55% yield. The IR spectrum of the title compound was identical to that of an authentic sample prepared as taught in U.S. Pat. No. 4,383,113.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04546179 |
|---|
| 출처 데이터셋 | uspto-grants-1985_10 |
|---|
| ORD ID | ord-b7c299a9824f4439972a45dd4673639e |
|---|
| 출처 메모 | uspto-grants-1985_10 |
|---|
