Bromine → 3-Bromo-5-(trifluoromethyl)pyridin-2(1H)-one

HRID 464129

반응식

HRID 464129 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6](=[O:9])[NH:7][CH:8]=1.[Br:12]Br>C(O)(=O)C>[Br:12][C:5]1[C:6](=[O:9])[NH:7][CH:8]=[C:3]([C:2]([F:1])([F:10])[F:11])[CH:4]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 1474432-Hydroxy-5-(trifluoromethyl)pyridine

생성물 1

HCID 134917753-Bromo-5-(trifluoromethyl)pyridin-2(1H)-one수율 75.8%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

0.4 g of 5-trifluoromethyl-2-pyridone was dissolved in 10 ml of acetic acid, and 0.4 g of bromine was added to the solution which was subsequently reacted for 4 hours while stirring. After completion of the reaction, the acetic acid was distilled off, and recrystallization was carried out from a mixed solvent of methylene chloride and n-hexane to obtain 0.45 g of the titled compound having a melting point of 162° to 165° C.

후처리

  1. customwas subsequently reacted for 4 hours
  2. customAfter completion of the reaction
  3. distillationthe acetic acid was distilled off
  4. customrecrystallization

출처 및 근거

ORD 기록
ord-e3812815ec9d471faee9967cbaf14091
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04546191

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