Acetic Acid → 3-Bromo-4-propylbenzoic acid

HRID 46415

반응식

HRID 46415 반응식
C(O)(=O)C.[N+]([O-])(O)=O.[CH2:9]([C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=1)[CH2:10][CH3:11].[Br:21]Br>O.[N+]([O-])([O-])=O.[Ag+]>[CH2:9]([C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=1[Br:21])[CH2:10][CH3:11]

참가 물질

7

반응물 4

HCID 176Acetic AcidHCID 944Nitric AcidHCID 24408BromineHCID 1376014-Propylbenzoic acid

생성물 1

HCID 203870433-Bromo-4-propylbenzoic acid

시약·촉매·용매 2

HCID 24470Silver Nitrate촉매HCID 962Water용매2회

실험 절차

To a mixture of 150 ml of glacial acetic acid, 33 ml of concentrated nitric acid and 25 ml of water, were added 8.2 g (0.05 moles) of parapropyl benzoic acid and 8.8 g (0.055 moles) of bromine. Then, at a temperature of 25° C., and over a period of half an hour, a solution of 8.5 g (0.05 moles) of silver nitrate in 25 cc of water was added. The solution was stirred for three hours, thirty minutes following which the suspended solid was removed by filtration and rinsed until neutral. Thereafter, the acid was dissolved in ethanol. Recrystallization from hexane yielded 4-propyl-3-bromo-benzoic acid.

후처리

  1. waitThen, at a temperature of 25° C., and over a period of half an hour
  2. customwas removed by filtration
  3. washrinsed until neutral
  4. dissolutionThereafter, the acid was dissolved in ethanol
  5. customRecrystallization from hexane

출처 및 근거

ORD 기록
ord-3a1733dc96d447078fc35cabe36a2cb0
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04173545

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