Ethyl orthopropionate → 4-Chloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline

반응식

[Cl:1][C:2]1[C:11]([NH:12][NH2:13])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:14](OCC)(OCC)(OCC)[CH2:15][CH3:16]>>[Cl:1][C:2]1[C:11]2[N:10]([C:14]([CH2:15][CH3:16])=[N:13][N:12]=2)[C:9]2[C:4]([N:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2

참가 물질

반응물 2

HCID 66995Ethyl orthopropionate

HCID 36588202-Chloro-3-hydrazinoquinoxaline

생성물 1

HCID 133857064-Chloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline수율 85%

실험 절차

2-Chloro-3-hydrazinoquinoxaline (4.5 g., 0.023 mole) the product of Example 1, was stirred with triethyl orthopropionate (50 ml.) at 100° C. for one hour. The mixture was cooled to room temperature and the white precipitate was collected by filtration and washed with cyclohexane to give 4.5 g. (85% yield) of 4-chloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 158°-160° C. Mass spectrum: m/e, 232 (P).

후처리

filtrationthe white precipitate was collected by filtration
washwashed with cyclohexane
customto give 4.5 g

출처 및 근거

ORD 기록: ord-a65a8a7417ac4f188bfb133e4412dec4
출처 데이터셋: uspto-grants-1985_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04547501

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