Dimethylamine → 4-Dimethylamino-[1,2,4]triazolo[4,3-a]quinoxaline
반응식
Cl[C:2]1[C:3]2[N:4]([CH:12]=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:15][NH:16][CH3:17]>CN(C)C=O>[CH3:15][N:16]([CH3:17])[C:2]1[C:3]2[N:4]([CH:12]=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2참가 물질
4
실험 절차
A slurry of 2.0 g. (0.01 mole) of 4-chloro-[1,2,4]triazolo[4,3-a]quinoxaline (the product of Example 2) in N,N-dimethylformamide (30 ml.) was saturated with dimethylamine gas and stirred at room temperature overnight. The mixture was poured over ice and the precipitate was removed by filtration. Recrystallization from ethanol gave 640 mg. (44% yield) of 4-dimethylamino-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 184°-186° C. Mass spectrum: m/e, 213 (P).
후처리
- additionThe mixture was poured over ice
- customthe precipitate was removed by filtration
- customRecrystallization from ethanol
- customgave 640 mg
출처 및 근거
- ORD 기록
- ord-9b54e143db7f48f399a73e6fb77c3b07
- 출처 데이터셋
- uspto-grants-1985_10
- 특허 번호
- US04547501
반응 노트
불러오는 중…