HCID 12951525, 화합물 → HCID 53742088, 화합물

HRID 464338노트

반응식

HRID 464338 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH3:6].CS[C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[CH:17][N:16]=1>N1C=CC=CC=1>[CH3:6][N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[CH:17][N:16]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1

참가 물질

4

반응물 2

HCID 12951525HCID 12951525, 화합물HCID 20262876N-(3-Aminopropyl)-N-methylpyridin-2-amine

생성물 1

HCID 53742088HCID 53742088, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-[N-(3-aminopropyl)-N-methylamino]pyridine (1.98 g) and 2-methylthio-5-(4-hydroxybenzyl)pyrimid-4-one (2.48 g) were heated together under reflux in pyridine (5 ml) for 24 hr. After stripping, the residue was triturated with water (pH adjusted to 7.0 with 2N hydrochloric acid). Recrystallisation from ethanol/water and again from methanol gave 2-[3-(N-methyl-N-pyrid-2-ylamino)propyl-amino]-5-(4-hydroxybenzyl) pyrimid-4-one, 2.4 g (66%) mp 109°-11° C. (analytical sample from methanol).

후처리

  1. customthe residue was triturated with water (
  2. customRecrystallisation from ethanol/water

출처 및 근거

ORD 기록
ord-a7b0736573d3426482a03bd4395dc92b
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04547506

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