Pyridinium chloride → 3-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-6-hydroxy-1,2,3,4-tetrahydrocarbazole

HRID 464488

반응식

HRID 464488 반응식
Cl.[C:2]1([C:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH:15]3[CH2:27][C:26]4[C:25]5[C:20](=[CH:21][CH:22]=[C:23]([O:28]C)[CH:24]=5)[NH:19][C:18]=4[CH2:17][CH2:16]3)[CH2:12][CH:13]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1>C1(C)C=CC=CC=1.C(N(CC)CC)C>[C:2]1([C:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH:15]3[CH2:27][C:26]4[C:25]5[C:20](=[CH:21][CH:22]=[C:23]([OH:28])[CH:24]=5)[NH:19][C:18]=4[CH2:17][CH2:16]3)[CH2:10][CH:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 10176127Pyridinium chlorideHCID 201837593-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-6-methoxy-1,2,3,4-tetrahydrocarbazole hydrochloride

생성물 1

HCID 201836973-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-6-hydroxy-1,2,3,4-tetrahydrocarbazole

시약·촉매·용매 1

HCID 22504574Toluene triethylamine용매

실험 절차

A mixture of 4.19 g of 3-(4-phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-6-methoxy-1,2,3,4-tetrahydrocarbazole hydrochloride and 3.5 g of pyridine hydrochloride is stirred at 160° for 3 hours. After the usual work-up, 3-(4-phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-6-hydroxy-1,2,3,4-tetrahydrocarbazole, Rf 0.2 (toluene/triethylamine 9:1), is obtained.

출처 및 근거

ORD 기록
ord-88d707a04d5b46339a84cbfdc9112204
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04547576

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