Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene, 1-bromo-3-(trifluoromethyl)- → 1-Benzhydryl-2-(m-trifluoromethylbenzimidoyl)azetidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene, 1-bromo-3-(trifluoromethyl)- | HCID 9817 | — |
| 반응물 | Magnesium | HCID 5462224 | — |
| 반응물 | 1-Benzhydrylazetidine-2-carbonitrile | HCID 19772072 | — |
| 반응물 | HCID 178506173 | HCID 178506173 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 1-Benzhydryl-2-(m-trifluoromethylbenzimidoyl)azetidine | HCID 20387049 | — |
반응 단계
Suspend m-trifluoromethylphenylmagnesium bromide in ether by adding a solution of 18 g of m-bromobenzotrifluoride in 30 ml of ether to a stirred suspension of 1.94 g of magnesium turnings in 20 ml of dry ether. Upon completion of addition, allow the reaction mixture to cool to room temperature and add 7.95 g of 1-benzhydryl-2-cyanoazetidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04173566 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-b96407d1931e4a2990162b28f74a60da |
| 출처 메모 | uspto-grants-1979_11 |