Ammonium Chloride → 2-(2,2,2-Trifluoroethoxy)pyridin-3-amine
반응식
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+]([O-])=O)=[CH:7][N:6]=1.[Cl-].[NH4+:17]>[Fe].C(O)C>[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[C:10]([NH2:17])=[CH:9][CH:8]=[CH:7][N:6]=1참가 물질
5
실험 절차
2-(2,2,2-Trifluoroethoxy)-5-nitropyridine (5.0 grams), powdered iron (15 grams), and ammonium chloride (25 grams) were refluxed in 3A ethanol until TLC detected no starting material (about 4 hours). The reaction mixture was filtered, washed with water, and solvents removed, yielding 1.0 gram of the product as a thin brownish liquid. NMR confirmed the identity of the product.
후처리
- customno starting material (about 4 hours)
- filtrationThe reaction mixture was filtered
- washwashed with water, and solvents
- customremoved
출처 및 근거
- ORD 기록
- ord-3817a0ce2dd540c5b34efa23b714c16d
- 출처 데이터셋
- uspto-grants-1979_11
- 특허 번호
- US04173639
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