Dimethylformamide → 2-[(4-Methoxyphenyl)amino]benzoic acid

HRID 464786

반응식

HRID 464786 반응식
Cl[C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:11][O:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+].CN(C)C=O>O>[CH3:11][O:12][C:13]1[CH:19]=[CH:18][C:16]([NH:17][C:2]2[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])=[CH:15][CH:14]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 7732P-AnisidineHCID 83742-Chlorobenzoic AcidHCID 11430Potassium Carbonate

생성물 1

HCID 2029182-[(4-Methoxyphenyl)amino]benzoic acid수율 76%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 52 g (0.33 mole) of 2-chlorobenzoic acid, 82 g (0.66 mole) of 4-methoxyaniline, 46 g (0.33 mole) of potassium carbonate, 5 g (0.025 mole) of cupric acetate and 150 ml of dimethylformamide was heated at reflux for two hours. The reaction mixture was cooled, 300 ml of water added and the mixture filtered. The filtrate was acidified with 50 ml of 6N hydrochloric acid, and the resulting solid was collected by filtration and recrystallized from acetonitrile to give 61 g of 2-(4-methoxyphenylamino)benzoic acid.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for two hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe mixture filtered
  5. filtrationthe resulting solid was collected by filtration
  6. customrecrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-e6d807f084a54bd7b8b146c779fc9dae
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04549016

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